BackgroundTrustworthy (i.e.low risk of bias) randomized clinical trials (RCTs) play an important role in evidence-based decision making.We aimed to systematically assess the risk of bias of trials published in high-impact endocrinology journals.MethodsWe searched the MEDLINE/PubMed database Feather Duster between 2014 and 2016 for phase 2-4 RCTs ev

Human immunodeficiency virus type 1 (HIV-1) has RNA genome and depends on host cellular machinery for most of its activities.Host cellular proteins modulate the expression and activity of viral proteins to combat the virus.HIV-1 proteins are known to regulate each other for the benefit of virus by exploiting these modulations.Here, we report that H

Intracellular Ca2+ ions represent a signaling Vacuum Mains Lead mediator that plays a critical role in regulating different muscular cellular processes.Ca2+ homeostasis preservation is essential for maintaining skeletal muscle structure and function.Store-operated Ca2+ entry (SOCE), a Ca2+-entry process activated by depletion of intracellular store

Although Blufensins (Bln) have important functions in the response of plants to biotic stress the precise functioning of Bln in wheat remains largely unknown.Here we isolated a Bln gene (TaBln4) from Suwon 11 infected by Puccinia striiformis f.sp.tritici (Pst).Expression of TaBln4 increased in host plants at the early stage of infection with a viru